US Route 224 runs east-west across the full width of Ohio, deciding on rural locales instead of gravitating toward larger cities. It cuts across Ohio in a way that splits about the northern fifth of the state from the rest of its land area (i.e. about one-fifth of Ohio is north of US Route 224). US Route 224 enters Ohio between Decatur, Indiana, and Van Wert, Ohio. From the state line, US Route 224 heads east, nudging northward at Van Wert. The route continues east with a slight northeastward component, passing through Ottawa and Findlay. From Findlay to Lodi, US Route 224 passes through rural farmland and a few smaller towns. At Lodi, US Route 224 joins US Route 42 on a bypass around downtown. Just beyond Lodi, US Route 224 is joined by the inception of Interstate 76, forcing US Route 224 to become a freeway until it reaches Akron. As Interstate 76 reaches Akron, it jumps northerly, leaving US Route 224 to continue eastward on a new Interstate, Interstate 277. Interstate 277 and US Route 224 concurrently bypass downtown Akron to the south, and at Interstate 77, US Route 224 continues as Interstate 277 ends. After a few more miles, US Route 224 goes back to being a rural surface road as it leaves Akron. US Route 224 enters the south side of the Youngstown area by reaching Canfield. It passes through Boardman and Poland, and then promptly enters Pennsylvania, bound for New Castle.