Ohio State Route 303 is a long, relatively straight east-west highway in the eastern half of northern Ohio. In the west, Ohio Route 303 begins by splitting from US Route 20 in Wakeman. It runs perfectly straight until it reaches Richfield, where it meets Ohio Route 176 and passes under Interstate 77. Beyond Richfield, Ohio Route 303 runs very close to Interstate 80, which comes from the northwest to turn easterly. Interstate 80 and Ohio Route 303 run eastward within a mile of each other until Ohio Route 303. This ending comes as Ohio Route 303 meets Ohio Route 82, between Garrettsville and Warren.