in Chicagoland. Click here for points south of Chicagoland.
^Southbound trailblazer at Interstate 80 near Mokena, June 2021.
US Route 45 spends a longer distance in the state of Illinois than any other route designation, spanning north-south from the Wisconsin border to the Kentucky border. It runs through Chicago's northwest, western, and southwestern suburbs, thence continuing south through Kankakee, Champaign, Effingham, and southernmost Illinois before crossing the Ohio River into Paducah, Kentucky. Between southwest Chicagoland and Effingham, US Route 45 closely parallels Interstate 57.