Indiana State Route 250 runs east-west in southern and southeastern Indiana, with a gap near Madison splitting the route into two separate segments. The very western end is at US Route 50 in Brownstown, and from there, Indiana Route 250 runs east to a gap starting at Indiana Route 7 between Madison and Dupont. Indiana Route 250 picks back up on the other side of the Jefferson Proving Ground, at US Route 421 north of Madison, and then comes to the penultimate eastern end at Indiana Route 156 at the town of Patriot, in Switzerland County along the Ohio River.