Interstate 57 runs from the City of Chicago south-southwesterly through Champaign and Effingham to the central backbone of southern Illinois, leaving the state near its southern tip into Missouri (NOT Kentucky).  Out of Interstate 57's 380 miles, 358 are spent in Illinois, and this mileage total is higher than that of any other Interstate's mileage in Illinois.  Interstate 57 serves as somewhat of an alternate to Interstate 55 between Chicago and Memphis; as Interstate 55 bows west to connect to St. Louis and come back southeast, Interstate 57 serves as a more direct alternative for long-term travelers.

​This page covers Interstate 57 in southern Illinois, from Effingham County south to the Missouri state line near Cairo. For points farther north in east-central Illinois, including Mattoon and Champaign, click here.  Exits will be listed from south to north.

​Interstate 57 enters Illinois crossing the Mississippi River out of Missouri, near Cairo, Illinois...
Interstate 57's exit 1 is a fountain interchange to Illinois 3 and US Route 51, which joins Interstate 57 from the south, connecting to Cairo...
Exit 8 is for Mounds Road...
Exit 18 is for the town of Ullin...
Exit 24 is for Dongola Road...
Exit 25 is a partial interchange allowing US Route 51 to split into a northwesterly direction toward Carbondale...
Exit 30 is for Illinois 146, with access to Vienna and Anna...
Exit 36 provides a link to Lick Creek Road...
Exit 40 is for Goreville Road...
Exit 44 leads to the western start of Interstate 24, signed as the way to Nashville...
Exit 45 is a kitty-corner folded diamond interchange to Illinois 148, which is signed without any associated control cities...
Exit 53 is a fountain interchange to Main Street in Marion, Illinois...
Exit 54A is a single-point interchange to Illinois 13, which connects to Carbondale and Harrisburg...
Exit 54B is Illinois's second diverging diamond, leading to "The Hill" Avenue in Marion (it's the second one chronologically)...
Exit 59 leads to Johnston City and Herrin...
Exit 65 is to Illinois 149, with access to West Frankfort and Zeigler:
Exit 71 provides access to Illinois 14, leading to Benton and Christopher...
Exit 77 is for Illinois 154, which links to Sesser...
Exit 83 leads to the small town of Ina...
Exit 92 reaches Interstate 64 east, signed as the way toward Louisville, as Interstate 64 joins Interstate 57 from the east...
Exit 94 is for Veterans Memorial Drive, in Mount Vernon...
Exit 95 is for Illinois 15, leading to Mount Vernon and Ashley:
Exit 96 sends Interstate 64 westbound to divert from Interstate 57 toward St. Louis:
Exit 103 is for the small Illinois town of Dix:
Exit 109 provides access to Illinois 161 and Centralia:
Exit 116 is a fountain interchange to US Route 50, Salem, and Sandoval:
Exit 127 is an exit to Kinmundy and Patoka:
Exit 135 is for Illinois 185, connecting to Farina and Vandalia:
Exit 145 provides access to the town of Edgewood:
Exit 151 is a trumpet interchange accessing the towns of Watson and Mason:
Exit 157 accesses Interstate 70 west toward St. Louis, as Interstate 70 joins Interstate 57 north around Effingham:
Exit 159 is for Fayette Avenue in Effingham, which provides access to US Route 40:
Exit 160 is for Illinois Routes 32 and 33:
Exit 162 is a fountain interchange to US Route 45, signed as a way to Sigel and Effingham:
Exit 163 is where Interstate 70 splits from Interstate 57 to continue east toward Indianapolis:
At mile marker 168, Interstate 57 crosses from Effingham County into Shelby County, ending the coverage on this page.  If you want to view information for points farther north along Interstate 57, click here for coverage of that route's path in east-central Illinois.
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