Ohio State Route 241 runs northeast from Millersburg to Massillon, then north from Massillon to Akron. The southwestern point of beginning is along Ohio Route 39, a few blocks east of Ohio Route 83. US Route 62 also follows Ohio Route 39 past that point of beginning. From there, Ohio Route 241 runs northeastward through Mount Eaton to Massillon. It cuts northerly to Ohio Route 172, then it follows Ohio Route 172 east for a short while in Massillon. The second half of Ohio Route 241 is a northward trek to the east side of Akron, passing through suburban sprawl sandwiched between Canton and Akron. The northern extent of Ohio Route 241 passes through an interchange with Interstate 76 to end at Ohio Route 18.