Indiana State Route 157 runs from Clay City to Bloomfield, where west-central Indiana meets southwestern Indiana. The southern portion from Worthington to Bloomfield is a bit of an alternate to US Route 231. The northern end in Clay City is at the concurrency of Indiana Routes 59 and 246. The southern end in Bloomfield is at Indiana Route 54, and US Route 231 as that highway comes from the east and turns south.