Indiana State Route 450 is a scenic, wiggly alternative to US Route 50 between Loogootee and Bedford in southwest Indiana. The eastern end is just a block shy of US Route 50's big junction with Indiana Routes 37 and 158 in Bedford; this eastern end is one block west of that junction on Indiana Route 158, which ends a block east at the aforementioned big junction. The western end, actually at US Route 50, is closer to Shoals than Loogootee, but traffic foreseeably would mainly turn westerly on US Route 50 to continue toward Loogootee. The tiny town of Williams lies in the middle of Indiana Route 450, a scenic riverside town in the hills home to a covered bridge.