States traversed: Indiana, Kentucky, Virginia, Tennessee, and North Carolina
US Route 421 runs from Michigan City, Indiana, southeast to the Atlantic Ocean near Wilmington, North Carolina. From the northern end at US Route 20 in Michigan City, US Route 421 heads mainly south but somewhat southeasterly through Indiana. It joins Interstate 465 around Indianapolis, and it joins Interstate 74 east to Greensburg, Indiana. At Greensburg, it splits from Interstate 74 to go south over the Ohio River at Madison, Indiana. US Route 421 continues south-southeasterly to Kentucky's southeastern corner. There, it crosses into southwestern Virginia, where it joins US Route 58 east through Bristol, Virginia, and Bristol, Tennessee. US Route 421 barely clips the northeastern corner of Tennessee before heading mainly eastward to Winston-Salem and Greensboro in North Carolina. After Greensboro, US Route 421 heads southeast to Wilmington and slightly beyond, ending at a parking lot for the Fort Fisher Ferry across the mouth of the Cape Fear River.
My photo for US Route 421 comes from Richmond, Kentucky, where US Route 421 is duplexed with US Route 25. Main Street in Richmond carries the business alignment of US Routes 25 and 421 through town; this photo comes from the northern end of that business alignment, where it meets the bypass route carrying the main alignments of US Route 25 and US Route 421. The junction is just barely east of an exit from Interstate 75 that I used for a pit stop in November 2016. This was on the way home from the second Gulf Coast trip that I took. Back to the nationwide main page. Back to the home page.