US Route 301 runs from northern Delaware to Florida's Gulf Coast. It is a very long route with a lot of importance, despite its 3-digit number. The northern end converges with Delaware Route 1, a tollway that parallels US Route 13, near Middletown, Delaware. US Route 301 heads southwesterly from here to cross the Chesapeake Bay Bridge concurrently with US Route 50.  Disembarking from the bridge at Annapolis, US Route 301 soon splits from US Route 50 to head south to the most downstream bridge over the Potomac River.  That bridge is where US Route 301 enters Virginia, bound for Richmond.  From Richmond, Virginia, to Santee, South Carolina, US Route 301 follows right alongside Interstate 95. At Santee, US Route 301 splits westerly from Interstate 95's corridor, toward Orangeburg, South Carolina. That's where US Route 301 starts doing its own thing through southern South Carolina and Georgia, becoming a decidedly more inland alternative to the newly-coastal Interstate 95.  In Florida, US Route 301 starts to angle toward Florida's western side.  US Route 301 passes through Ocala and grazes the eastern edge of Tampa.  The route ends at US Route 41 in Sarasota, Florida.

My photo for US Route 301 comes from its junction with Florida Route 44 in Wildwood, Florida.  This is very near the northwestern end of the Florida Turnpike. The sign assembly depicted faces east for westbound travelers on Route 44. This photo was part of the detour to Florida, taken at the end of the second Gulf Coast trip in November 2016.
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