States traversed: Mississippi and Alabama, plus tiny forays into Georgia and Louisiana.
Interstate 59 runs southwest, from the northwest corner of Georgia to Slidell, Louisiana; the objective is to connect the cities of Chattanooga, Tennessee, and New Orleans, Louisiana, which lie just barely beyond each extent of the highway corridor. The overwhelming majority of Interstate 59 is in Alabama and Mississippi. All of Interstate 59 follows along the southern part of the US Route 11 corridor. The northern terminus is at Interstate 24, just five minutes southwest of Chattanooga. From there, Interstate 59 clips the northwest corner of Georgia to head into Alabama, where it connects with Gadsden, Birmingham, and Tuscaloosa. At Birmingham, Interstate 20 joins Interstate 59 south from the east. Crossing into Mississippi, Interstate 59 promptly enters Meridian, where Interstate 20 splits off to continue west. Interstate 59 does its own thing, though, heading south-southwest through Hattiesburg. The highway only makes it eleven miles into Louisiana before ending at an interchange with Interstate 10, which also hosts the eastern end of Interstate 12. Staying straight south will carry traffic on Interstate 10 toward New Orleans.