^Looking east from the intersection with Ohio 193 west of Andover, October 2022.

In Ohio, US Route 6 spans the full width of the northern part of the state.  In northwestern Ohio and northeastern Ohio, US Route 6 is the second-most northerly US Highway in Ohio, after US Route 20.  However, in north-central Ohio, US Route 6 is the northernmost, staying north of US Route 20.  From Fremont to Cleveland, US Route 6 stays alongside the waters of Lake Erie.  But US Route 6 tends to stay straight east-west outside of that range.  US Route 6 enters Ohio between Butler, Indiana, and Edgerton, Ohio.  It stays south of Toledo, running through Napoleon and Bowling Green, instead.  At Fremont, US Route 6 turns northeasterly to meet the lakeside, serving Sandusky and Huron.  From Huron to Cleveland, US Route 6 hugs right along Lake Erie's southern shore.  Beyond Cleveland, US Route 6 heads due east as the shoreline traces northeasterly. At Andover, US Route 6 jumps northerly to a different alignment headed east for the Pennsylvania border, to get around the Pymatuning Reservoir (even though Ohio Route 85 continues straight easterly over the Reservoir, anyway).

My photo of US Route 6 signage in Ohio comes from US Route 250 in Sandusky. The junction marker that appears in the photo announces the upcoming junction to northbound traffic on US Route 250, which ends at this junction with US Route 6. This photo was taken in October 2023, during the trip to northwestern Ohio and the Lake Erie Islands.
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