^The first westbound trailblazer seen by those turning away from Indiana 26 in Upland, April 2025.
Indiana State Route 22 runs east-west in north-central Indiana, serving as the main east-west route through Kokomo. It's duplexed with US Route 35 from Kokomo to Gas City, a stretch comprising the majority of its length. It converges with Indiana Route 26 in Upland, where it ends.