US Route 601 runs north-south across central portions of North Carolina and central portions of South Carolina.  The northern end is near the northern border of North Carolina, at US Route 52 in Mount Airy; the southern end is near the southern tip of South Carolina, at US Route 321.  In North Carolina, US Route 601 runs almost due north-south, serving as the next major longitudinal corridor east of Interstate 77 (and US Route 21).  For that reason, it passes around the east side of Charlotte, entering South Carolina.  It cuts through Camden and Orangeburg in South Carolina. Ultimately, US Route 601 ends at US Route 321, at a point west of Ridgeland and north of Hardeeville.

My photo of US Route 601 comes from Orangeburg, South Carolina. The sign assembly depicted faces north at the southeast corner of the intersection, and downtown Orangeburg lies just to the south, or just into the photo's background.  US Route 601 penetrates into the downtown area, whereas US Route 21 and US Route 178 run east-west bypassing downtown just to the north (save for US Route 21's business route). This photo was taken in July 2019, as part of the day I spent detouring around South Carolina.
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