Indiana State Route 58 runs east-west in southwestern and south-central Indiana, from Carlisle to Bedford to the southern end of the Columbus, Indiana area. The eastern end has a bit of a northeast-southwest tilt, connecting Bedford and Columbus. Much of the route is curvy, jagged, and rural. Oddly, it stays north of Indiana Route 56, in defiance of Indiana's state highway numbering convention. The western end is at Indiana Route 63, in Merom, to Indiana Route 11 at Walesboro, just south of Columbus.