Illinois Route 14 runs east-west in southern Illinois from DuQuoin, east to the Wabash River. For most of its length, Illinois Route 14 is the next east-west route south of Interstate 64, passing through Perry, Franklin, Hamilton, and White Counties.
Illinois 14's western end is at US Route 51 on the south side of DuQuoin:
At the unincorporated place called Mulkeytown, Illinois 14 meets the northern end of Illinois 184:
Still in Benton, Illinois 14 turns off of Illinois 37 to resume heading easterly:
At McLeansboro, Illinois 14 encounters Illinois 142, at the south end of that route's stint as a pair of one-way streets; this means the southbound side of Illinois 142 joins Illinois 14 east for one block, while the northbound side crosses straight across Illinois 14:
Just outside of Enfield, Illinois 14 crosses US Route 45:
At Carmi, Illinois 14 joins Illinois 1 north, though this point might as well be the new eastern endpoint of Illinois 14 (see below):
At Crossville, Illinois 14 splits from Illinois 1 to head east:
At the site of a former bridge over the Wabash River, Illinois 14 ends across the river from New Harmony, Indiana. Illinois 14 used to cross a bridge here into New Harmony, where it became Indiana State Route 66, but the bridge was closed about ten years ago, leaving Illinois 14 to simply dead-end at the river in the present day.