Interstate 64 is an important expressway in the middle of the country, from the Mississippi River Valley to the Atlantic Ocean.  The western end is at Interstate 70 in Wentzville, Missouri, just west of St. Louis.  Interstate 64 then forms the main freeway through downtown St. Louis, duplexed with US Route 40.  Interstate 64 crosses the Mississippi River on the same bridge as Interstate 55, splitting from Interstate 55 upon reaching the state of Illinois.  Interstate 64 continues east across southern Illinois and southernmost Indiana west of Louisville, Kentucky.  The next move is to cross the Ohio River into Louisville, continuing east across eastern Kentucky into West Virginia.  Interstate 64's first foray into West Virginia involves a journey through Huntington.  It continues east from there to Charleston, joining Interstate 77 south along the tolled West Virginia Turnpike.  The tolls end as Interstate 64 splits from Interstate 77 at Beckley.  Interstate 64 continues west over the mountains of West Virginia and western Virginia, reaching Charlottesville, Richmond, and Williamsburg in Virginia.  The final stretch of Interstate 64 has an overall southerly path across the Hampton Roads area in Virginia, crossing the titular Hampton Roads Bridge and Tunnel.  The highway comes from the north, wrapping around Norfolk and Portsmouth in a clockwise fashion, to end at Interstate 264 and Interstate 664 on the southwest side of Portsmouth. From Louisville to Hampton Roads, Interstate 64 follows alongside US Route 60, except for the section between Staunton to Richmond in Virginia; that section is paralleled by US Route 250.

My photo of an Interstate 64 marker comes from Interstate 77's southernmost interchange with a surface road before joining Interstate 64 south in Charleston, West Virginia.  The sign assembly faces southeast down a street connecting to US Route 119, which sits just behind the aperture.  Interstate 77 crosses the background of the photo; a few miles to the north is the southern terminus of Interstate 79. The appeal of taking route marker photos at this location is clear: I can get three photos for three Interstates at the same time! This photo was taken along the Virginia trip in April 2021.
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