US Route 378 is a good example of a US highway that's very important to one state and almost meaningless to all of the other states.  US Route 378 is an east-west route across the middle of South Carolina, connecting many important locales in that state; it barely extends west into Georgia, ending at US Route 78 in the town of Washington.  From that western endpoint in Washington, Georgia, US Route 378 heads east through Columbia and Sumter to end in Conway at US Routes 501 and 701.  Much of the traffic reaching the eastern end of US Route 378 continues southeast onto US Route 501, which accesses Myrtle Beach.  At the other end, traffic reaching the western end of US Route 78 can continue west on US Route 78 to reach Athens and Atlanta in Georgia.

An older photo for US Route 378 once took center stage on this page, but that photo has been moved to the bottom of the page.  The official photo, from which I extracted the shield image above, is this one right here:

My photo of US Route 378 is this one, taken at the western junction with South Carolina Highway 41.  This junction forms the western extent of a short concurrency between US Route 378 and the state highway, and it sits about halfway between Conway and Lake City in South Carolina.  This trailblazer shown in the photo is a rare and precious treasure, in my opinion, because it's one of the few US highway markers in South Carolina using the full-sized font width known as Series D. This photo was taken in June 2024 while in transit from Myrtle Beach to Congaree National Park.

Another photo for US Route 378 once served as the main photo for that route on this page. That older photo is shown below.

This older photo for US Route 378 is a junction marker that faces south in Columbia, South Carolina, along Huger Street, a street carrying US Routes 176 and 321.  In July 2019, I spent a day driving around South Carolina, as a detour from a vacation to the Wilmington, North Carolina area.  US Route 1 and US Route 378 are concurrent along the road that runs from left to right across the intersection in the background of the photo.
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