Ohio State Route 43 runs southeast, then south, then southeast again between Cleveland and Steubenville. It stretches all across northeastern Ohio. The first stretch begins at US Route 422 in Cleveland, following Ohio Route 14 for its first maneuvers. At the southern reaches of Cleveland, near the border with Cuyahoga Heights, Ohio Route 14 splits to head easterly as Ohio Route 43 continues southeast into Garfield Heights. Ohio Route 43 serves Bedford Heights and Solon on the way out of the Cleveland Metroplex, and then it bends southerly at Aurora. Here begins the straight southerly stretch to Canton, by way of Kent. Ohio Route 43 is actually a pair of one-way streets in Canton, where it serves the city center. A short jog eastward on the US Route 30 freeway leads Ohio Route 43 to its final southeastern stretch in the hilly countryside of eastern Ohio. This final southeastern stretch cuts across Carrollton, ending in downtown Steubenville at Ohio Route 7.
My photo of Ohio State Route 43 signage shows a northbound trailblazer serving travelers leaving the junctions with Ohio Route 646 and US Route 22. Ohio Route 43 meets the eastern end of Ohio Route 646 just barely north of its interchange with US Route 22. The trailblazer in the picture sits just north of the intersection with Ohio Route 646. This photo was taken on the northwestern edge of Wintersville in March 2021, as part of the tour around southeastern Ohio (this was just about the northeastern corner of that trip).