US Route 641 runs north-south in western Kentucky and western Tennessee. The northern end is in Marion, Kentucky, at US Route 60. The southern end is at US Route 64 near Clifton, Tennessee, at a junction that's just a little bit north of the triple point where the borders between Tennessee, Alabama, and Mississippi, all meet. US Route 641 doesn't reach any major cities, but it does connect to places like Benton, Murray, and Eddyville, in Kentucky, as well as Paris, Camden, and Clifton in Tennessee. US Route 641 does not connect to its parent route, US Route 41, in its current state. However, I believe it was routed north and east along US Route 60 in the past, so it connected to US Route 41 in Henderson, Kentucky, back in the old days.