US Route 150 in Indiana, runs from the Terre Haute area south to Vincennes, and east-southeast from Vincennes to cross into Louisville, Kentucky. US Route 150 enters Indiana from Illinois between Paris, Illinois, and Terre Haute, and then heads south into Terre Haute where it joins US Route 41. It follows US Route 41 south all the way to Vincennes, then turns east onto US Route 50 all the way to the town of Shoals. At Shoals, US Route 150 splits from its second long concurrency in a row, to join Interstate 64 just west of New Albany, Indiana, and Louisville, Kentucky. US Route 150's final four miles are along Interstate 64, and it crosses into the city of Louisville via a bridge over the Ohio River. US Route 150 spends more than half of its length in Indiana concurrent with another route.