US Route 401 runs from northeastern North Carolina to central South Carolina. It runs south from US Route 1 at Norlina, North Carolina, through Raleigh to Fayetteville. At Fayetteville, US Route 401 bends southwesterly, joining US Route 15 into South Carolina. US Route 401 splits from US Route 15, just to flank that route to its southeast until ending in Sumter, another town that's also reached by US Route 15; in other words, US Route 401 is just an alternate route to US Route 15 in South Carolina. The southern end in Sumter bends west past US Route 15 to reach its final intersection with US Route 76 (the business alignment).