^Looking north from Exit 1 in Jeffersonville, February 2022.
Interstate 65 is the most dominant north-south Interstate in Indiana, linking Gary and Chicagoland to Indianapolis, and then to the Louisville area.  Interstate 65 starts at the Indiana Toll Road, which carries Interstate 90, and cuts southeast through Lafayette to meet Indianapolis at Indiana's center; from there, Interstate 65 heads south through Columbus, Indiana, to cross the Ohio River into downtown Louisville, Kentucky. 

This page covers the portion of Interstate 65 in southern Indiana, from Bartholomew County south to the Kentucky border.  In other words, this page talks about mile markers 0 through 79 in Indiana. For points north of here, in central Indiana, including Indianapolis, click here.

​Exits on this page, as well as on the other Interstate 65 pages are listed from south to north, in accordance with the national mileage numbering convention.

To start things off, here's a photo of the Indiana welcome sign that greets travelers entering the state from the south. Interstate 65 enters Indiana crossing the Ohio River bridge out of Louisville, Kentucky:
​The first exit heading northbound comes right off Interstate 65's bridge over the Ohio River, and it's actually numbered "Exit 0". The exit leads to Court Avenue and 6th Street in Jeffersonville:
Exit 1 in Jeffersonville leads to 10th Street, Stansifer, and a road to New Albany, whether you're coming from the north or south along Interstate 65; from the north, exit 1 also leads to an offramp to US Route 31, which joins Interstate 65 from the south:
Exit 2 is for Eastern Blvd. in Jeffersonville:
Exit 4 leads to US Route 31 north, plus Lewis & Clark Parkway:
Exit 5 leads to Veterans Parkway, still in Jeffersonville:
Exit 6A is the first part of an interchange leading to Interstate 265, duplexed with Indiana Route 62; this first ramp leads eastward on Indiana Route 265, which isn't yet signed as an Interstate, toward Jeffersonville:
Exit 6B is the latter ramp of the interchange, connecting to Interstate 265 and Indiana Route 62 west toward New Albany:
Exit 7 is for Indiana Route 60, which connects to Salem, Indiana:
Exit 9 is for the towns of Sellersburg and Speed, linking to a road formerly designated as Indiana Route 311:
Exit 16 is for Memphis Road, next to the town of Memphis, Indiana:
Exit 19 is for Indiana Route 160, connecting to Henryville and Charlestown:
Exit 29 leads to Indiana Route 56, either west toward Salem, or east toward Scottsburg (the southbound half of this interchange is a cloverleaf, with exit 29A pointing drivers east and exit 29B pointing drivers westbound):
Exit 34 leads to Indiana Route 256, either to the west or to the east toward Austin (the southbound half of this interchange is a cloverleaf, with exit 34A pointing drivers east toward Austin, and exit 34B pointing drivers west to nowhere in particular):
Exit 36 leads to US Route 31, with access to Austin and Crothersville:
Exit 41 leads to Indiana Route 250 and Uniontown:
Exit 50A is the first half of a cloverleaf interchange, and this first ramp leads to US Route 50 east toward North Vernon:
Exit 50B, the latter ramp in the cloverleaf, leads to US Route 50 west toward Seymour and Brownstown:
Exit 55 is for Indiana Route 11, providing access to Seymour and Jonesville:
Exit 64 provides access to Indiana Route 58, Ogilville and Walesboro:
Exit 68 is a single-point interchange to Indiana Route 46, linking to Columbus, Bloomington, and Nashville:
Exit 76A is the first half of a partial cloverleaf interchange with US Route 31; this first ramp leads to US Route 31 south, toward Taylorsville and Columbus:
Exit 76B, the latter ramp in the partial cloverleaf interchange, leads to US Route 31 north toward Edinburgh:
At mile 78, Interstate 65 crosses into Johnson County. For points north on Interstate 65 in Johnson County and elsewhere in central Indiana, click here.
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