Interstate 64 runs east-west across southern Illinois, connecting St. Louis, Missouri, to southernmost Indiana and Louisville, Kentucky. It meets Interstate 57 at Mount Vernon, in the heart of southern Illinois, but besides Mount Vernon and the Metro-East, Interstate 64 stays mainly in rural areas of southern Illinois.
Interstate 64 enters Illinois crossing the Mississippi River on the Poplar Street Bridge out of Saint Louis, Missouri, along with Interstate 55 and US Route 40...
Exit 1 provides access to the south on Illinois 3, toward Cahokia, as Illinois 3 joins Interstates 64 and 55 from the south:
Exit 1B is for 13th Street and Tudor Avenue in East St. Louis:
Exit 2A provides access to Barack Obama Avenue, the Eads Bridge, and the (unmentioned) western end of Illinois 15:
Exit 2B is only accessible from the southbound lanes, but it provides access to the MLK Bridge: