^Looking east from exit 130 (Illinois Route 1), February 2022.
Interstate 64 runs east-west across southern Illinois, connecting St. Louis, Missouri, to southernmost Indiana and Louisville, Kentucky. It meets Interstate 57 at Mount Vernon, in the heart of southern Illinois, but besides Mount Vernon and the Metro-East, Interstate 64 stays mainly in rural areas of southern Illinois.
Interstate 64 enters Illinois crossing the Mississippi River on the Poplar Street Bridge out of Saint Louis, Missouri, along with Interstate 55 and US Route 40...
Interstate 64 enters Illinois crossing the Mississippi River on the Poplar Street Bridge out of Saint Louis, Missouri, along with Interstate 55 and US Route 40...
Exit 1 provides access to the south on Illinois 3, toward Cahokia, as Illinois 3 joins Interstates 64 and 55 from the south:
Exit 1B is for 13th Street and Tudor Avenue in East St. Louis:
Exit 2A provides access to Barack Obama Avenue, the Eads Bridge, and the (unmentioned) western end of Illinois 15:
Exit 2B is only accessible from the southbound lanes, but it provides access to the MLK Bridge:
Exit 3 allows Interstate 64 to split from Interstate 55 and US Route 40, at an interchange where Interstate 70 joins Interstate 55 and US Route 40, but that's not the concern of the newly-liberated Interstate 64:
A secondary ramp at exit 3 allows Interstate 64 to access St. Clair Avenue, and to send Illinois 3 off on its town toward the north:
Exit 4A is for Baugh Avenue in East Saint Louis...
Exit 4B is for 25th St. in East Saint Louis:
Exit 6 is for Illinois 111, also known as Kingshighway in this region:
Exit 7 is an auxiliary lane to a cloverleaf interchange with Interstate 255, north toward Chicago or south toward Memphis. Note that at this interchange, US Route 50 comes from the south and Interstate 255 and merges onto Interstate 64 east:
Exit 9 is a fountain interchange to Illinois 157 and Caseyville:
Exit 12 is a partial cloverleaf interchange to Illinois 159, signed as a way to Belleville and Collinsville:
Exit 14 leads to a former alignment of US Route 50, signed as a way to O'Fallon, Illinois:
Exit 16 doesn't mention a road name, but it leads to O'Fallon and Shiloh:
Exit 19A is the first half of a cloverleaf, and it leads to the northern end of Illinois 158 and Scott Air Force Base:
Exit 19B, at the second half of the cloverleaf, sends US Route 50 to split eastward toward Carlyle:
Exit 21 is to Rieder Road:
Exit 23 is for Illinois 4, Mascoutah, and Lebanon:
Exit 27 is for Illinois 161 and New Baden (use this exit to access Illinois 160):
Exit 34 is to the town of Albers:
Exit 41 provides a link to Illinois 177 and Okawville:
Exit 50 connects to Illinois 127, signed as a way to Carlyle or Nashville, Illinois:
Exit 61 provides ramps to US Route 51, which can connect to Ashley and Centralia:
Exit 69 is for Woodlawn, Illinois:
Exit 73 provides access to Interstate 57, as Interstate 64 joins Interstate 57 south around Mount Vernon:
The next exit is along Interstate 57, and it uses Interstate 57's exit numbers--so the next exit is Exit 95 to Illinois 15, accessing Mount Vernon and Ashley:
The next exit is number 94, for Veterans Memorial Drive:
Interstate 64 then splits from Interstate 57, regaining its own path and its own exit numbers (this exit is number 78):
Exit 80 is for Illinois 37 in Mount Vernon:
Exit 89 provides connectivity to Belle Rive and Bluford:
Exit 100 is to Illinois 242, which can take travelers to Wayne City or McLeansboro:
Exit 110 accesses US Route 45, signed as a connection to Norris City and Fairfield:
Exit 117 is to the town of Burnt Prairie:
Exit 130 connects to Illinois 1, Grayville and Carmi:
After 131 miles in Illinois, Interstate 64 crosses the Wabash River into Indiana:
