^Northbound reassurance marker in the heart of Manteno, May 2022.
Illinois Route 50 runs north-south from the near northern suburbs of Chicago, through sections of the city of Chicago and the southern suburbs, to come to an eventual end in Kankakee. In Chicagoland, Illinois 50 is known as Cicero Avenue.
The northern beginning of Illinois 50 occurs as US Route 41 turns from southerly to southeasterly in Skokie; here, Illinois 50 continues straight south, in the wake of US Route 41...
Alongside Lincolnwood, Illinois 50 crosses US Route 14...
Around the Portage Park neighborhood of Chicago, Illinois 50 crosses Illinois 19:
Before exiting the north side of Chicago, Illinois 50 also crosses Illinois 64...
In Kankakee, right by the county courthouse, Illinois 50, as a pair of one-way streets, crosses Illinois 17:
The southern end of Illinois 50 is on the south side of Kankakee, where US Routes 45 and 52 arrive from the west on the same road, to take over for Illinois 50 on the same road to head farther south: