US Route 178 runs in northwestern South Carolina and southern South Carolina, with a slight foray north into western North Carolina. The northern end is at Rosman, North Carolina, at US Route 64, about six miles from the border with South Carolina. US Route 178 heads south straight for that border, spending almost all of its time in South Carolina.  It passes southward through Anderson and turns southeasterly through Greenwood, Saluda, and Orangeburg, staying southwest of Interstate 26.  US Route 178 ends by converging with US Route 78 between Interstate 95 and the Charleston area, near the village of Ridgeville.  US Route 178 manages to fall short of reaching Charleston, pass just to the west of Greenville, and pass southwest of Columbia; thus, it avoids reaching any of South Carolina's most prominent cities.

My photo of US Route 178 was taken in Orangeburg, South Carolina, where US Route 301 meets the tight loop used by US Routes 21 and 178 to wrap around the eastern and northern sides of town.  US Route 301 is actually heading westward into this photo's background (i.e. the aperture faces west).  I took this photo during my random detour around South Carolina in July 2019; I would take my photos for US Route 21 and US Route 601 also in Orangeburg, right after taking this one.

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