Illinois Route 146 is an important east-west route in southernmost Illinois, spanning the width of the state. In particular, it enters Illinois using the bridge out of Cape Girardeau, Missouri, and proceeds east to Cave-in-Rock in the southeast corner of the state. It connects many destinations in southern Illinois, including four county seats and some sightseeing spots in the Shawnee National Forest.
Illinois 146's western beginning is a crossing over the Mississippi River from Cape Girardeau, Missouri, on an impressive cable-stayed suspension bridge:
Several miles east of Cape Girardeau, Illinois 146 joins Illinois 3 north:
Illinois 146 then splits off of Illinois 3 to continue east:
Illinois 127 comes from the north to follow Illinois 146 east into Jonesboro:
At a long-standing roundabout in Jonesboro, Illinois 127 departs to continue south as Illinois 146 continues east into Anna: