^Looking east on US Route 24 (and US Route 421) where it joins US Route 421 eastward in Raymond, August 2024.
In Indiana, US Route 24 bisects the northern half of the state (so 1/4 of Indiana sits north of US Route 24). US Route 24 enters Indiana from Illinois concurrent with US Route 52, which soon splits away to leave US Route 24 heading largely due east through some small towns like Remington and Monticello. In the central third of Indiana, US Route 24 follows the east-west portion of the Wabash River through Logansport, Peru, Wabash, and Huntington. From Huntington east through the eastern third of northern Indiana, US Route 24 cuts northeasterly to the Fort Wayne area, leaving US Route 224 in its wake as the new route continuing straight east. In the Fort Wayne area, US Route 24 uses Interstate 69 north and Interstate 469 southeast to absolve INDOT of maintaining any responsibility of the roadway through Fort Wayne itself. East of Fort Wayne, US Route 24 heads east-northeast toward Toledo, crossing into Ohio eleven miles after splitting off of Interstate 469 at Fort Wayne.