Illinois Route 78 is a long north-south route in northwestern and west-central Illinois.  It's a continuation of Wisconsin Highway 78, running southward from the Wisconsin border all the way to Jacksonville along the Interstate 72 corridor, connecting a great variety of different towns.

Illinois 78 starts as the continuation of Wisconsin Highway 78 crossing the Wisconsin border, entering Warren, Illinois...

Heading south, Illinois 78 joins US Route 20 west into Stockton, Illinois:

In Stockton, Illinois 78 splits off of US Route 20 to resume its southerly pathing:

At Mount Carroll, Illinois 78 crosses the concurrent couple of US Route 52 and Illinois 64:

Just south of that junction, Illinois 78 meets the northern end of Illinois 40:

West of Morrison, Illinois 78 joins US Route 30 east:

Then, when inside the town of Morrison, Illinois 78 splits from US Route 30 to resume its southerly motion:

North of Prophetstown, Illinois 78 meets Interstate 88 at a diamond interchange:

Near Hooppole, Illinois 92 comes from the east to join Illinois 78 south:

A short duplex of less than one mile is created, and then Illinois 92 splits from Illinois 78 to go west:

Approaching Annawan, Illinois 78 meets Interstate 80 at a diamond interchange:

In Annawan, Illinois 78 crosses US Route 6...

In Kewanee, Illinois 78 meets the eastern endpoint of Illinois 81:

A few blocks to the south, still in Kewanee, Illinois 78 picks up US Route 34 which joins from the east:

A few miles south of Kewanee, Illinois 78 and US Route 34 concurrently pass by the northwestern endpoint of Illinois 91:

Less than a mile after that, US Route 34 turns westward, whereupon Illinois 78 splits off to continue heading south:

Only a few miles west of Toulon, Illinois 17 joins from the west for less than a mile to follow Illinois 78 south:

Illinois 17 soon departs from Illinois 78 to continue eastward:

Near the town of Laura, Illinois 78 meets the western terminus of Illinois 90...

Only about a mile later, Illinois 78 meets US Route 150, which joins it from the west:

Just north of Interstate 74, Illinois 78 splits to head westerly, independently of US Route 150, which heads easterly (access to Interstate 74 is provided by heading south from this intersection):

After crossing over Interstate 74 and turning back south, Illinois 78 meets Illinois 8, which joins from the east:

After passing through Elmwood, Illinois 78 turns southerly again at a wye, leaving Illinois 8 to run independently westward:

Illinois 78 meets Illinois 116 and joins that route west into Farmington:

In Farmington, Illinois 78 splits from Illinois 116 to head southerly again:

Illinois 9 comes from the west, and, at a junction in Canton, it joins Illinois 78 south:
​(the signage here fails to mention Illinois 9 east)

Leaving Canton, Illinois 9 splits from Illinois 78 to continue easterly:

South of Canton, Illinois 78 meets the northern end of Illinois 100:

In the unincorporated place known as "Little America, Illinois," Illinois 78 joins US Route 24 west:

A few miles to the west, lies a T-intersection where each approach carries a distinct duplex!  Illinois 78 splits from US Route 24 to head south, but the western leg of the intersection carrying US Route 24 also carries Illinois 97, which turns onto the southern leg:

Illinois 78 and Illinois 97 are concurrent now, and this concurrency joins US Route 136 east, across the Illinois River from Havana:

The three routes cross the river into Havana, and Illinois 78 promptly splits from US Route 136 and Illinois 97 to head south:

At the town of Virginia, Illinois 78 crosses Illinois 125:

In Jacksonville, Illinois 78 reaches its southern end, at Illinois 104 (US Route 67 isn't at this junction, but it's less than a mile to the right):

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