US Route 220 is a long north-south route across the Piedmont and the uplands of the Mid-Atlantic States. It begins in South Waverly, Pennsylvania, on the border with New York; this point of beginning is at the eastern Interstate 86. Its southern end is in Rockingham, North Carolina, at US Route 1. US Route 220 has nothing to do with its parent route of US Route 20--at least, not anymore. It's a very long route for an eastern three-digit US highway. US Route 220 heads south from South Waverly across the whole of Pennsylvania, snaking southwesterly through Williamsport to Interstate 80. At Interstate 80, US Route 220 is whisked onto a freeway through State Collage and Altoona, designated as Interstate 99. At Bedford, Interstate 99 ends at Interstate 70/76, though US Route 220 continues beyond. US Route 220 cuts across Cumberland, Maryland, and then it promptly finds itself in the mountains of eastern West Virginia. Eventually, US Route 220 situates itself in the state of Virginia-- its western edge to be exact. It passes through Roanoke, where it meets Interstate 81. US Route 220 passes through Martinsville, Virginia, to reach Greensboro, North Carolina, where Interstate 73 joins US Route 220 south. Interstate 73 and US Route 220 continue through Asheboro together, and then they both end in Rockingham. US Route 220 converges with US Route 1 just north of US Route 74.
My photo of US Route 220 comes from Asheboro, North Carolina, where it meets Business US Route 64. These junction markers serve eastbound travelers on US Route 64's business alignment. (A bypass alignment bypasses around the north side of Asheboro.) These junction markers also mention Interstate 73 and Interstate 74, which both join US Route 220 through the middle of North Carolina. This photo was taken in April 2024 during my trip across the Delmarva and the Carolinas.